Native MS based protein characterization
Ion Mobility based conformational analysis
HDX-MS based structural mapping of proteins
Fluorescence Spectroscopy based Membrane Structure analysisÂ
Structural Omics
Proteomics
Nano-LC ESI proteomics
PTM analysis
Disease biomarker discovery
Mass Spectromery based Imaging
Spatial mapping across biopsy tissues:
   DESI Imaging for small molecules
   MALDI Imaging of Proteins and peptides
Molecular Medicine
Metabolomics & Lipidomics
LC-MS metabolomics
Lipid profiling
Clinical metabolite biomarkers
Scientific Approaches
Molecular Medicine
Red Blood Cell Dysfunction and Biomarker Discovery in CSFP
Coronary Slow Flow Phenomenon (CSFP) is a cardiac microvascular disorder in which blood flows slowly through the coronary arteries despite the absence of major blockage. It is linked to endothelial dysfunction, inflammation, oxidative stress, and platelet abnormalities. Our research focuses on understanding the molecular basis of CSFP and identifying potential biomarkers and therapeutic targets for improved diagnosis and treatment.
Environmental Quinones and Red Blood Cell Dysfunction
This research focuses on understanding how harmful chemicals from air pollution and cigarette smoke affect red blood cells (RBCs). Using advanced biochemical and mass spectrometry-based techniques, the study explores how these pollutants disrupt RBC structure and function through oxidative stress, potentially contributing to cardiovascular and circulatory complications. The work also aims to develop reliable methods for detecting these toxic compounds in human samples to support environmental exposure monitoring and health risk assessment.
Mass Spectrometry-Based Biomarker Discovery in COPD
This research focuses on understanding the molecular changes associated with Chronic Obstructive Pulmonary Disease (COPD) using advanced mass spectrometry–based approaches. The study aims to identify potential biomarkers linked to disease development and progression through comprehensive analysis of biological samples. By combining analytical and molecular profiling techniques, the work seeks to improve the understanding of COPD and support the development of better diagnostic and prognostic strategies.
Current Research Areas
Nanoparticle-Based Approaches for Iron Deficiency Anemia: Proteomics and Tissue Imaging-Based Evaluation
Iron Deficiency Anemia (IDA) is one of the most common nutritional disorders, especially affecting women and children in India. It develops when the body lacks enough iron to produce healthy hemoglobin, reducing the blood’s ability to carry oxygen efficiently. This can lead to fatigue, weakness, poor concentration, and reduced physical performance. Ongoing research aims to develop safer and more effective approaches for iron supplementation and food fortification to improve public health.
Molecular Profiling of Cervical Cancer, Ovarian Cancer, Urinary-Bladder Cancer Tissues Using Imaging Mass Spectrometry
This research focuses on understanding cancer at the molecular level using advanced tissue imaging and omics-based approaches. By studying the distribution of biomolecules within cancer tissues, the work aims to identify disease-related molecular changes and potential biomarkers associated with cancer progression. The study combines imaging, histopathology, and molecular analysis to improve the understanding of cancer biology and support the development of better diagnostic and prognostic strategies.
Novel Therapeutic Approaches for Sickle Cell Disease
This research focuses on understanding the molecular mechanisms underlying sickle cell disease (SCD), particularly the abnormal sickling of red blood cells and the role of oxidative stress in disease progression. The study aims to explore redox-based therapeutic strategies to reduce red blood cell damage and improve disease outcomes, contributing to the development of safer and more effective approaches for SCD management.