Waters Centre of Innovation Award January 2013
Waters Synapt G2-Si
Advancing Molecular Medicine Through Precision Research
Our laboratory integrates advanced mass spectrometry and multi-omics technologies to decode disease mechanisms and discover novel clinical biomarkers for precision intervention.
Deciphering the Path of Molecular Progress
The Molecular Medicine Research Lab is an academic center dedicated to advancing human health through precision proteomics. By integrating high-definition mass spectrometry with advanced molecular techniques, our multidisciplinary team decodes the underlying drivers of complex diseases. We foster a collaborative research environment to bridge discovery science and clinical practice, accelerating the delivery of next-generation biomarkers and therapeutic insights.
Featured Discoveries
Explore a concise selection of our most impactful recent findings in molecular medicine, offering a quick glimpse into our ongoing contributions to the field.
Srinivasu, B.Y., Arumugaperumal, A., Mitra, A. et al. Effect of nanoparticle exposure in a living system: probed by quantification of Fetuin-B in plasma proteome and kidney tissue imaging using MALDI imaging mass spectrometry in a rat model. J Nanopart Res 23, 125 (2021). https://doi.org/10.1007/s11051-021-05251-z
Quantification of Fetuin-B might be used to monitor the toxicity upon exposure to Nanoparticle (NP) in a biological system. Increased concentration of NPs displayed downregulation of Fetuin-B in plasma with a strong synergetic relationship with an increase in the pro-inflammatory cytokines and the differential distribution of α-Enolase in kidney tissue in a rat model.Â
Journal of Nanoparticle Research, Vol. 23, Article 125, 2021
Mathew B, Srinivasan K, Pradeep J, Thomas T, Murthy SK, Mandal AK. Downregulation of apolipoprotein A-IV in plasma & impaired reverse cholesterol transport in individuals with recent acts of deliberate self-harm. Indian J Med Res. 2019 Oct;150(4):365-375. doi: 10.4103/ijmr.IJMR_1842_17. PMID: 31823918; PMCID: PMC6902365.
downregulation of Apo A-IV, impaired reverse cholesterol transport, decreased level of esterified and total cholesterol and lower level of HDL were observed in individuals with deliberate self-harm compared to matched controls. The observed downregulation of Apo A-IV may be the link between the previously reported association of altered cholesterol levels with impulsivity and suicide.
Indian Journal of Medical Resaerch; October, 2019; 150(4):365-375
Mitra A, Choubey SK, Das R, Rout P, Sridhar TS, et al. (2024) Differential Expression of Proteins in Human Prostate Cancer: A MALDI-MS Based Imaging Study. JSM Clin Oncol Res 12(1): 1072.
In this study, MALDI mass spectrometry based tissue imaging platform was used to image the distribution of multiple proteins on human prostate tissues which were diagnosed with cancer. We observed the differential expression of three proteins, vinculin, ribonuclease T2 and 60 kDa heat shock protein across the tissue sections in the regions that were found to be pathologically significant in the diagnosis of prostate cancer.
Indian Journal of Medical Resaerch; October, 2019; 150(4):365-375