Dr. Amit Kumar Mandal
Professor
Department of Biological Sciences, IISER Kolkata
Structural biologist and proteomics researcher specializing in mass spectrometry, structure–function correlation of proteins, and molecular mechanisms of human diseases.
65+
Papers
18
h-index
36
i10
970
Citations
Research Interests
Current research in the lab focuses on the molecular basis of human diseases using advanced proteomics and structural biology approaches.
Proteomics
Metabolomics
Mass Spectrometry Imaging
Biomarker Studies
Redox Biology
Clinical Proteomics
Oxidative Stress
Redox-Switch mechanisms
Metabolite Profiling
COPD & Kidney Disease
Human Disease Markers
MDD Metabolic pathways
Spatial Characterization
Molecular Mapping
Tissue Proteomics
Lipidomic Imaging
Hemoglobinopathies
Sickle Cell & Anemia
Cardiovascular Diseases
Prostate & Cervical Cancer
Education
Ph.D. (Biophysics/Biochemistry)
2004
Bose Institute
1992
M.Sc. (Physical Chemistry)
University of Calcutta
B.Sc. (Chemistry Honours)
1990
University of Calcutta
Professional Experience
Professor
Indian Institute of Science Education and Research (IISER) Kolkata
2025 – Present
Associate Professor
Indian Institute of Science Education and Research (IISER) Kolkata
2019 – 2025
Professor
St. John’s Research Institute
2011 – 2019
Associate Professor
St. John’s Research Institute
2007 – 2011
Research Associate
Indian Institute of Science (IISc) Bangalore
Supervisor: Prof. P. Balaram
2005 – 2006
Research Associate
Supervisor: Prof. Paul Horwitz
University of Texas Health Science Center
2002 – 2003
Publications & Achievements
Publications
Conformational perturbation of SARS-CoV-2 spike protein using N-acetyl cysteine: an exploration of probable mechanism of action to combat COVID-19
Utsab Debnath, Amrita Mitra, Varun Dewakar, Yenamandra.S. Prabhakar, Raghu Tadala, Kiran Krishnan, Padmakar Wagh, Umashankar Velusamy, Aastha Baliyan, Anura V Kurpad, Parthasarathi Bhattacharyya, Amit Kumar Mandal
Books and Technical Write Ups
Application of Hydrogen/Deuterium Exchange Mass Spectrometry in Structural Biology and Molecular Medicine
Bindu Yadaganahalli Srinivasu, Amit Kumar Mandal
“Advances in Biochemistry and Applications in Medicine” Volume-2
Publisher: Open Access eBooks; 848 N. Rainbow Blvd, #5486, Las Vegas, NV 89107, USA
Application of Mass Spectrometry to Analyse Protein Structure within a Live Cell
Bindu Yadaganahalli Srinivasu, Amit Kumar Mandal
“Advances in Biochemistry and Applications in Medicine” Volume-3
Publisher: Open Access eBooks; 848 N. Rainbow Blvd, #5486, Las Vegas, NV 89107, USA
Sickle Cell Hemoglobin
Amit Kumar Mandal, Amrita Mitra, Rajdeep Das
“Vertebrate and Invertebrate Respiratory Proteins, Lipoproteins and other Body Fluid Proteins”, Subcellular Biochemistry, Volume 94, pages 297-322
Publisher: Springer Nature Switzerland AG, 2020
Structural Proteomics Takes Aim at Disease: A combination of H/DX-MS and IMS will help to explore the basis of functional failures in proteins linked to medical conditions
Amrita Mitra, Amit Kumar Mandal
The Analytical Scientist. 2013, 0613: 303
CAREER HIGHLIGHTS
Centers of Innovation Award, Waters Corporation (USA)
Patent
Low-cost electrochemical disposable sensor for measuring glycated hemoglobin
Siva Rama Krishna Vanjari, Navakanta Bhat, Sampath Srinivasan, Bharadwaj Amrutur, Chakrapani Kalapu, Amit Kumar Mandal
United States Patent; Patent No.: US 8,702,931 B2, Date of Patent: Apr.22, 2014
Research Projects & Funding
The lab has been supported by intramural and competitive extramural funding from national and international agencies.
INR 15+ Crores
Total Cumulative Extramural Funding
- Principal Investigator and Co-Principal Investigator on major projects funded by ICMR, DST, DBT, and DRDO.
- Research support spanning clinical proteomics, biomarker discovery, and deep molecular characterization of complex diseases.
- Ongoing and completed projects focusing on the molecular mechanisms of hemoglobinopathies, cardiovascular diseases, and other critical health disorders.
Teaching & Mentorship
- Courses taught in biochemistry, biophysics, structural biology, and proteomics at UG and PG levels.
- Supervision of Ph.D. scholars and mentoring of project students and interns in molecular medicine and proteomics.
- Contribution to curriculum development and establishment of a state-of-the-art proteomics laboratory.
Actively involved in teaching and mentoring at the undergraduate, postgraduate, and doctoral levels.
Contact Information
Direct Contact
Email: amitkm@iiserkol.ac.in
Phone: 033 6136 0000 ext. 1350
Institutional Address
C-04, 3rd Floor, Research Complex, Indian Institute of Science Education and Research (IISER) Kolkata, Mohanpur, Nadia - 741246, West Bengal, India